Sujet de la discussion : MedeSpace.Net :: Syndrome de l'homme raide.

Publié par lemediateur le 22-01-2009 10:20
#7

lemediateur écrit :
effectivement la maladie dont je parlais et qui était souvent associée au syndrome de l'homme raide est le DIABETE.
Alors question: Comment expliquer cette association diabète- syndrome de l'homme raide.

Stiff man syndrome
"This term includes a range of rare conditions which are characterized by muscle rigidity with or without spasms. This includes the stiff man syndrome which is characterized by axial rigidity involving the paraspinal muscles which leads to a hyperlordotic posture of the back and an abnormal gait often described as walking through treacle. These patients often have muscle spasms in response to sensory stimuli with an exaggerated startle response. The patients characteristically have antiglutamic acid decarboxylase antibodies which may account for the high incidence of diabetes mellitus and other autoimmune disorders in this condition. Treatment is usually with baclofen and diazepam, although clonazepam, sodium valproate, and vigabatrin have all been used successfully. Immunosuppressive therapy is often disappointing, although it may benefit some patients."

Extrait de : Oxford Textbook of Medicine 4th edition (March 2003): by David A. Warrell (Editor), chapitre 24.13.11 Disorders of movement (excluding Parkinson's disease)